When setting up the automatic reply and out of office from your Outlook 2010 having Exchange 2010 you might have the problem with a pop-up saying “Your automatic reply settings cannot be displayed because the server is unavailable”.
I have managed to solve this with a DNS record in your infrastructure. Create the following SRV record to fix the issue.
Port Number: 443
On the client PC run the following to refresh the DNS. Make sure you run the CMD as Administrator
This should fix the problem and the user will be prompted to enter his Out of office settings.